Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Within 16 hours of meeting Sepsis-3 definition:

- Vasopressor requirement to maintain MAP ≥65 mmHg.

- Lactate >2 mmol/L.

- Suspected/ confirmed infection.

Exclusion Criteria:

Any of the following:

- Already on or planned for RRT.

- Goals-of-care limitations.

- Active bleeding or on ECMO\IABP.

- Cirrhosis, severe TR, or anatomical barriers to ultrasound (e.g.: nonremovable surgical dressings).

- Post-cardiac arrest or liver\kidney transplant patients.

- Severe metabolic/electrolyte derangements (e.g.: K <3, Na >155)

- Inability to measure fluid balance accurately.